Vrije Universiteit Brussel

 

Beta Cell protection

Type 1 diabetes results from severe autoimmune/inflammatory cell mass destruction. Type 2 diabetes is initiated by insulin resistance of the body and progresses by increased metabolic stress imposed on cells leading to destruction of cell mass. So in both types of diabetes, the cell mass (number of differentiated, functional cells) is a crucial factor. Our general aim is to control the cell mass by finding drugs that stimulate cell regeneration. An important target for this is to promote the survival of cells by protecting them in stressful conditions (so they can proliferate). We conduct research on small molecules that protect cells against metabolic stress (ER-stress and oxidative stress), like the phytochemicals aspalathin and phenyl propenoic acid glucoside originally discovered in South African Rooibos.

 


©2015-2016 • DIFF • Vrije Universiteit Brussel • Faculteit Geneeskunde & Farmacie • Laarbeeklaan 103 • 1090 Jette • Tel.: 02/477.44.57 • lucbo@vub.ac.be