Vrije Universiteit Brussel



Full Papers (since 2000, in international peer-reviewed journals)

Joosten L, Brom M, Peeters H, Bos D, Himpe E, Bouwens L, Boerman O, Gotthardt M. Measuring the Pancreatic ß Cell Mass in Vivo with Exendin SPECT during Hyperglycemia and Severe Insulitis . Mol Pharm. 2019 Aug 8. doi: 10.1021/acs.molpharmaceut.9b00728. IF = 4.4

Baldan J, Houbracken I, Rooman I, Bouwens L. Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture . Sci Rep. 2019 Mar 11;9(1):4040. doi: 10.1038/s41598-019-40481-1. IF = 4.1

Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik & Nick Devoogdt. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells . Scientific Reports. 2017. Scientific Reports 7, Article number: 15130 doi:10.1038/s41598-017-15417-2. IF = 4.3

Song I, Roels S, Martens GA, Bouwens L. Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds. PLoS One. 2017 Oct 17;12(10):e0186480. doi: 10.1371/journal.pone.0186480. eCollection 2017. IF = 2.8

Houbracken I, Bouwens L. Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells. Sci Rep. 2017 Oct 3;7(1):12643. doi: 10.1038/s41598-017-12721-9. IF = 4.3

Masini M, Marselli L, Himpe E, Martino L, Bugliani M, Suleiman M, Boggi U, Filipponi F, Occhipinti M, Bouwens L, De Tata V, Marchetti P. Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes. PLoS One 2017 Jun 15;12(6):e0179398. doi: 10.1371/journal.pone.0179398. eCollection 2017. IF = 2.8

Eddy Himpe, Daniel A. Cunha, Imane Song, Marco Bugliani, Piero Marchetti, Miriam Cnop, Luc Bouwens. Phenylpropenoic acid glucoside from rooibos protects pancreatic beta cells against cell death induced by acute injury. PLoS One 2016 Jun 14;11(6):e0157604. doi: 10.1371/journal.pone.0157604. eCollection 2016. IF = 3.1

Mfopou JK, Houbracken I, Wauters E, Mathijs I, Song I, Himpe E, Baldan J, Heimberg H, Bouwens L. Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of ß-cell neogenesis. Biosci Rep. 2016 May 6;36(3). pii: e00329. doi: 10.1042/BSR20150259. Print 2016 Jun. IF =2.6

Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, Baeyens L. Reprogramming of human pancreatic exocrine cells to ß-like cells. Cell Death Differ. 2015 Jul;22(7):1117-30. doi: 10.1038/cdd.2014.193. Epub 2014 Dec 5. IF = 8.2

Mathijs I, Xavier C, Peleman C, Caveliers V, Brom M, Gotthardt M, Herrera PL, Lahoutte T, Bouwens L. A standardized method for in vivo mouse pancreas imaging and semiquantitative ß cell mass measurement by dual isotope SPECT. Mol Imaging Biol. 2015 Feb;17(1):58-66. doi: 10.1007/s11307-014-0771-y. IF = 2.0

Song I, Patel O, Himpe E, Muller CJ, Bouwens L. Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin. PLoS One. 2015 Oct 9;10(10):e0140148. doi: 10.1371/journal.pone.0140148. eCollection 2015. IF = 3.2

Mfopou JK, Bouwens L. Diabetes: ß cells at last. Nat Rev Endocrinol. 2015 Jan;11(1):5-6. doi: 10.1038/nrendo.2014.200. Epub 2014 Nov 11. IF = 13.3

Song I, Muller C, Louw J, Bouwens L. Regulating the beta cell mass as a strategy for type-2 diabetes treatment. Curr Drug Targets. 2015;16(5):516-24. Review. IF = 3.0

De Vos J, Mathijs I, Xavier C, Massa S, Wernery U, Bouwens L, Lahoutte T, Muyldermans S, Devoogdt N. Specific targeting of atherosclerotic plaques in ApoE(-/-) mice using a new Camelid sdAb binding the vulnerable plaque marker LOX-1. Mol Imaging Biol. 2014 Oct;16(5):690-8. doi: 10.1007/s11307-014-0731-6. IF = 2.8

Mathijs I, Da Cunha DA, Himpe E, Ladriere L, Chellan N, Roux CR, Joubert E, Muller C, Cnop M, Louw J, Bouwens L. Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis. Mol Nutr Food Res. 2014 Oct;58(10):1980-90. doi: 10.1002/mnfr.201400211. Epub 2014 Aug 4. IF = 4.6

De Waele E, Wauters E, Ling Z, Bouwens L. Conversion of human pancreatic acinar cells toward a ductal-mesenchymal phenotype and the role of transforming growth factor ß and activin signaling. Pancreas. 2014 Oct;43(7):1083-92. doi: 10.1097/MPA.0000000000000154. IF = 3.0

Zheng F, Put S, Bouwens L, Lahoutte T, Matthys P, Muyldermans S, De Baetselier P, Devoogdt N, Raes G, Schoonooghe S. Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis. J Nucl Med. 2014 May;55(5):824-9. doi: 10.2967/jnumed.113.130617. Epub 2014 Mar 31. IF = 6.2

Mfopou JK, Geeraerts M, Dejene R, Van Langenhoven S, Aberkane A, Van Grunsven LA, Bouwens L. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies. Stem Cell Res. 2014 Jan;12(1):166-77. doi: 10.1016/j.scr.2013.10.004. Epub 2013 Oct 23. IF =3.7

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol. 2013 Nov 17. doi: 10.1038/nbt.2747. [Epub ahead of print] IF = 32.4

Mfopou JK, Geeraerts M, Dejene R, Van Langenhoven S, Aberkane A, Van Grunsven LA, Bouwens L. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies. Stem Cell Res. 2013 Oct 23;12(1):166-177. doi: 10.1016/j.scr.2013.10.004. [Epub ahead of print] IF = 4.5

Mfopou JK, Bouwens L. Differentiation of pluripotent stem cells into pancreatic lineages. Med Sci (Paris) . 2013 Aug-Sep;29(8-9):736-43. doi: 10.1051/medsci/2013298012. Epub 2013 Sep 5. Review. French. IF =

Bouwens L, Houbracken I, Mfopou JK. The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol. 2013 Oct;9(10):598-606. doi: 10.1038/nrendo.2013.145. Epub 2013 Jul 23. IF = 11.0

Sui L, Bouwens L, Mfopou JK. Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells. Int J Dev Biol. 2013;57(1):1-12. doi: 10.1387/ijdb.120115ls. Review. IF = 2.6

Sui L, Geens M, Sermon K, Bouwens L, Mfopou JK. Role of BMP signaling in pancreatic progenitor differentiation from human embryonic stem cells. Stem Cell Rev. 2013 Oct;9(5):569-77. doi: 10.1007/s12015-013-9435-6. IF =4.5

Wauters E, Sanchez-Arevalo Lobo VJ, Pinho AV, Mawson A, Herranz D, Wu J, Cowley MJ, Colvin EK, Ngawi Njicop E, Sutherland RL, Liu T, Serrano M, Bouwens L, Real FX, Biankin AV, Rooman I. Sirtuin-1 regulates acinar to ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res. Cancer Res. 2013 Apr 1;73(7):2357-67. doi: 10.1158/0008-5472.CAN-12-3359. Epub 2013 Jan 31. IF = 7.9

Bouwens L. SSEA4: a marker leading the way towards curing diabetes? Biomark Med. 2012 Dec;6(6):711-3. doi: 10.2217/bmm.12.83. No abstract available. IF = 2.63

Houbracken I, Baeyens L, Ravassard P, Heimberg H, Bouwens L. Gene delivery to pancreatic exocrine cells in vivo and in vitro. BMC Biotechnol. 2012 Oct 22;12:74. doi: 10.1186/1472-6750-12-74. IF = 2.4

Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T. Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines. Cell Metab. 2012 Oct 3;16(4):449-61. doi: 10.1016/j.cmet.2012.09.001. Epub 2012 Sep 20. IF = 13.7

Sui L, Mfopou JK, Geens M, Sermon K, Bouwens L. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun. 2012 Sep 28;426(3):380-5. doi: 10.1016/j.bbrc.2012.08.098. Epub 2012 Aug 29. IF = 2.48

Mathijs I, Houbracken I, Bouwens L. Genetic lineage tracing of beta cell neogenesis. Methods Mol Biol. 2012;933:317-22. doi: 10.1007/978-1-62703-068-7_21. IF =

Houbracken I, Mathijs I, Bouwens L. Lineage tracing of pancreatic stem cells and beta cell regeneration. Methods Mol Biol. 2012;933:303-15. doi: 10.1007/978-1-62703-068-7_20. IF =

Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, Bouwens L, Lahoutte T, De Baetselier P, Raes G, Devoogdt N, Van Ginderachter JA. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Cancer Res. 2012 Aug 15;72(16):4165-77. doi: 10.1158/0008-5472.CAN-11-2994. Epub 2012 Jun 19. IF = 7.9

Sui L, Mfopou JK, Chen B, Sermon K, Bouwens L. Transplantation of human embryonic stem cell-derived pancreatic endoderm reveals a site-specific survival, growth and differentiation. Cell Transplant. 2012 Apr 2. [Epub ahead of print] IF=

Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552. Epub 2012 Mar 8. IF = 8.7

Mfopou JK, Baeyens L, Bouwens L. Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro. Diabetologia. 2012 Apr;55(4):1024-34. doi: 10.1007/s00125-011-2434-8. Epub 2012 Jan 12. IF = 6.8

Houbracken I, de Waele E, Lardon J, Ling Z, Heimberg H, Rooman I, Bouwens L. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology. 2011 Aug;141(2):731-41, 741.e1-4. doi: 10.1053/j.gastro.2011.04.050. Epub 2011 May 4. IF = 11.7

Hakonen E, Ustinov J, Mathijs I, Palgi J, Bouwens L, Miettinen PJ, Otonkoski T. Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation. Diabetologia. 2011 Jul;54(7):1735-43. doi: 10.1007/s00125-011-2153-1. Epub 2011 Apr 21. IF = 6.8

Pinho AV, Rooman I, Reichert M, De Medts N, Bouwens L, Rustgi AK, Real FX. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut. 2011 Jul;60(7):958-66. doi: 10.1136/gut.2010.225920. Epub 2010 Dec 30. IF = 10.1

Houbracken I, Bouwens L. The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement. Rev Diabet Stud. 2010 Summer;7(2):112-23. doi: 10.1900/RDS.2010.7.112. Epub 2010 Aug 10. Review. IF = 0.793

Mfopou JK, Chen B, Sui L, Sermon K, Bouwens L. Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells. Diabetes. 2010 Sep;59(9):2094-101. doi: 10.2337/db10-0439. IF = 8.9

Flamez D, Roland I, Berton A, Kutlu B, Dufrane D, Beckers MC, De Waele E, Rooman I, Bouwens L, Clark A, Lonneux M, Jamar JF, Goldman S, Maréchal D, Goodman N, Gianello P, Van Huffel C, Salmon I, Eizirik DL. A genomid-basd approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. Diabetologia 53(7):1372-83, 2010. IF = 7.0

Mfopou JK, Chen B, Mateizel I, Sermon K, Bouwens L. Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Gastroenterology 138(7):2233-45, 2010. IF = 12.0

Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 17(6):849-60, 2009. IF = 13.4

Baeyens L, Bonné S, Bos T, Rooman I, Peleman C, Lahoutte T, German M, Heimberg H, Bouwens L. Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology 136(5):1750-60, 2009. IF = 12.7

Baeyens L, Bouwens L. Can beta-cells be derived from exocrine pancreas? Diabetes Obes Metab 10Suppl4:170-8, 2008. IF = 4.2

Xu X, D’Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132(2):197-207, 2008. IF = 31.2

Lardon J, Corbeil D, Huttner WB, Ling Z, Bouwens L. Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas 36(1):e1-6, 2008. IF = 2.7

Mfopou JK, Bouwens L. Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected. Differentiation 76(2):107-17, 2008. IF = 3.2

Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L. Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development . Stem Cells 25(5):1156-65, 2007. IF = 7.7

Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L. Ngn3 expression during postnal in vitro beta cell neogenesis induced by the JAK/STAT pathway . Cell Death Differentiation 13(11):1892-9, 2006. IF = 7.5

Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H, Bouwens L. Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. American Journal of Pathology 169(4):1206-14, 2006. IF = 6.9

Bouwens L. Beta cell regeneration. Current Diabetes Reviews 2(1):3-9, 2006.

De Breuck S, Baeyens L, Bouwens L. Expression and function of leukemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49(1):108-16, 2006. IF = 6.4

Mfopou JK, Willems E, Leyns L, Bouwens L. Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation. International Journal of Developmental Biology 49(8):915-22, 2005. IF = 2.4

Bouwens L, Rooman I. Regulation of pancreatic beta cell mass. Physiological Reviews 85(4): 1255-1270, 2005. IF = 34

Lardon J, Bouwens L. Metaplasia in the pancreas. Differentiation 73:278-286, 2005. IF=4

Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I and Bouwens L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 48(1):49-57, 2005. IF= 5.7

Timmers M, Vekemans K, Vermijlen D, Asosingh K, Kuppen P, Bouwens L, Wisse E, Braet F. Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis. International Journal of Cancer 112(5):793-802, 2004, IF = 4.4

Bouwens L. Islet morphogenesis and stem cell markers. Cell Biochemistry and Biophysics 40: 81-88, 2004, IF = 3.2

Lardon J, De Breuck S, Rooman I, Van Lommel L, Schuit F, Kruhoffer M, Orntoft T, Bouwens L. Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology 39:1499-1507, 2004, IF = 9.5

Lardon J, Huyens N, Rooman I, Bouwens L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch 444:61-65, 2004, IF = 2.4

Rooman I and Bouwens L Combined gastrin and Epidermal Growth Factor treatment induces islet regeneration and restores normoglycemia in C57Bl6-J mice treated with alloxan Diabetologia 47:259-265, 2004, IF = 5.7

Rasilainen S, Ylipaasto P, Roivainen M, Bouwens L, Lapatto R, Hovi T, Otonkoski T. Mechanisms of beta cell death during restricted and unrestricted enterovirus infection. J Med Virol. 72:451-461, 2004, IF = 2.4

De Breuck S, Lardon J, Rooman I, Bouwens L. Netrin expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 46:926-933, 2003, IF = 5.7

Paris M, Bernard-Kargar C, Berthault MF, Bouwens L, Ktorza A. Specific and Combined Effects of Insulin and Glucose on Beta-Cell Growth In Vivo in Adult Rats. Endocrinology 144:2717-2727, 2003, IF = 5.0*

Lardon J, Rooman I, Bouwens L. Nestin expression in rat pancreatic stellate cells and angiogenetic endothelial cells. Histochem Cell Biol 117: 535-540, 2002, IF = 2.6*

Rooman I, Lardon J, Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 51:686-690, 2002, IF = 8.3*

Rooman I, Lardon J, Schuit F, Flamez D, Bouwens L. Mitogenic effect of gastrin and expression of gastrin receptors by duct-like cells of rat pancreas. Gastroenterology 121:940-949, 2001, IF = 12.7*

Pipeleers D, Hoorens A, Marichal-Pipeleers M, Van de Casteele M, Bouwens L, Ling Z. Role of pancreatic ß-cells in the process of ß-cell death. Diabetes 50: S52-S57, 2001, IF = 8.3

Rooman I, Heremans Y, Heimberg H, Bouwens L. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43: 907-914, 2000, IF = 5.7*

Heimberg H, Bouwens L, Heremans Y, Van de Casteele M, Lefebvre V, Pipeleers D. Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein IPF-1. Diabetes 49:571-579, 2000, IF = 8.3*

Roivainen M, Rasilainen S, Ylipaasto P, Nissinen R, Ustinov J, Bouwens L, Eizirik DL, Hovi T, Otonkoski T. Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells. J Clin Endocrinol Metab 85: 432-440, 2000, IF = 5.9

Cnop M, Grupping A, Hoorens A, Bouwens L, Pipeleers-Marichal M, Pipeleers D. Endocytosis of low density lipoprotein by human pancreatic ß-cells and uptake in lipid-storing vesicles which increase with age. Am J Path 156: 237-244, 2000, IF = 6.9

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